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FOX04-DRI 10mg (Proxofim)
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FOX04-DRI 10mg (Proxofim)

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Rated 5 out of 5

$284.99

Researched Benefits:

  • Facilitates analysis of FOXO4-p53 interaction inhibition for investigating targeted senolysis
  • Supports investigation into p53-mediated mitochondrial apoptosis in senescent cell assays
  • Enables research on selective elimination of senescent fibroblasts and myofibroblasts
  • Useful for evaluating homeostatic recovery and cellular rejuvenation in aging-related models
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Description

FOXO4-DRI 10 mg (Proxofim) is a synthetic D-retro-inverso peptide engineered to disrupt the FOXO4-p53 interaction that allows senescent cells to resist apoptosis. By reinstating p53-mediated cell death in these cells, FOXO4-DRI functions as a potent senolytic agent in pre-clinical studies, opening new avenues for research into age-related degeneration and chronic inflammatory conditions.

Key Features:

  • Manufactured under stringent cGMP-like conditions to ensure ≥99 % purity and batch-to-batch consistency.

  • Lyophilized powder for maximum stability; reconstitutes rapidly in sterile distilled water or buffer.

  • Extensively validated by HPLC and mass spectrometry for precise molecular integrity.

Applications:

  • Investigating senolytic mechanisms and selective clearance of senescent cells.

  • Exploring therapeutic potential in age-associated tissue dysfunction and metabolic decline.

  • Assessing downstream effects on oxidative stress, insulin signaling, and cancer cell plasticity.

Specifications and Documentation

  • Material Safety Data Sheet (MSDS): Coming Soon.

  • Handling and Storage Instructions: Coming Soon.

FOXO4-DRI has emerged as a valuable research tool for probing cellular senescence, regenerative biology, and longevity science, offering investigators a robust platform for advancing anti-aging and disease-modifying strategies.

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